Haloperidol dose

Haloperidol is a typical butyrophenone type antipsychotic that exhibits high affinity dopamine D 2 receptor antagonism and slow receptor dissociation kinetics. [42] It has effects similar to the phenothiazines . [17] The drug binds preferentially to D 2 and α 1 receptors at low dose (ED 50 = and  mg/kg, respectively), and 5-HT 2 receptors at a higher dose (ED 50 =  mg/kg). Given that antagonism of D 2 receptors is more beneficial on the positive symptoms of schizophrenia and antagonism of 5-HT 2 receptors on the negative symptoms, this characteristic underlies haloperidol's greater effect on delusions, hallucinations and other manifestations of psychosis. [43] Haloperidol's negligible affinity for histamine H 1 receptors and muscarinic M 1 acetylcholine receptors yields an antipsychotic with a lower incidence of sedation, weight gain, and orthostatic hypotension though having higher rates of treatment emergent extrapyramidal symptoms .

CONDITIONS OF USE: The information in this database is intended to supplement, not substitute for, the expertise and judgment of healthcare professionals. The information is not intended to cover all possible uses, directions, precautions, drug interactions or adverse effects, nor should it be construed to indicate that use of particular drug is safe, appropriate or effective for you or anyone else. A healthcare professional should be consulted before taking any drug, changing any diet or commencing or discontinuing any course of treatment.

The article states that haloperidol is "marginally effective." It cites a source that does not make this claim. In fact, any expert and many patients can tell you that this is not the case. Also, the article goes on to say that the citation "may be overly generous," which is a very subjective claim. Then it says that haloperidol "should only be used if other treatments are not a possibility" - this is also not specifically stated in the article, and is not consistent with the clinical opinion of most experts. I think it's unwise to be giving medical advice like this.

Sixteen trials with nineteen different randomised dose comparisons were included. No studies reported data on relapse rates, quality of life and none compared >- mg/day haloperidol to higher dose ranges. Using low doses (>3-/day) did not clearly result in loss of efficacy (no clinically important improvement in global state, versus >-15mg/day n=48, 1 RCT, RR CI to ; versus >15-35mg/day n=81, 2 RCTs, CI to ). Doses of haloperidol in the range of >3- mg/day had a lower rate of development of clinically significant extrapyramidal adverse effects than higher doses (clinically significant extrapyramidal adverse effects, versus >-15mg/day n=64, 2 RCTs, RR CI to ; versus >15-35mg/day n=144, 3 RCTs RR CI to , NNH 3 CI 2 to 6; versus >35mg/day n=86, 2 RCTs, RR CI to ). All other comparisons between dose ranges did not yield statistically significant differences, but several, particularly with lower dose ranges, were underpowered to detect clinically meaningful differences.

Haloperidol dose

haloperidol dose

Sixteen trials with nineteen different randomised dose comparisons were included. No studies reported data on relapse rates, quality of life and none compared >- mg/day haloperidol to higher dose ranges. Using low doses (>3-/day) did not clearly result in loss of efficacy (no clinically important improvement in global state, versus >-15mg/day n=48, 1 RCT, RR CI to ; versus >15-35mg/day n=81, 2 RCTs, CI to ). Doses of haloperidol in the range of >3- mg/day had a lower rate of development of clinically significant extrapyramidal adverse effects than higher doses (clinically significant extrapyramidal adverse effects, versus >-15mg/day n=64, 2 RCTs, RR CI to ; versus >15-35mg/day n=144, 3 RCTs RR CI to , NNH 3 CI 2 to 6; versus >35mg/day n=86, 2 RCTs, RR CI to ). All other comparisons between dose ranges did not yield statistically significant differences, but several, particularly with lower dose ranges, were underpowered to detect clinically meaningful differences.

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